a highly aggressive B-cell non-Hodgkin lymphoma marked by rapid tumor growth and MYC gene translocations. Three clinical forms are recognized: endemic (seen primarily in equatorial Africa and strongly associated with
Epstein–Barr virus), sporadic (occurring worldwide in children and adults), and immunodeficiency-associated (linked to conditions such as
HIV or post-transplant immunosuppression). Treatment typically involves intensive combination chemotherapy, often with targeted agents. [identified by and named after Denis Parsons Burkitt (1911–1993), British surgeon]