adj. of or relating to any interaction between the immune system and the central nervous system (CNS). These interactions include the ways in which the immune system protects the CNS from infectious agents and injury-induced inflammation, along with the ways in which the CNS modulates the immune response. Studies suggest neuroimmune involvement in the pathogenesis of numerous conditions, such as multiple sclerosis, autism spectrum disorder, depression, and schizophrenia; research is ongoing.