a characteristic withdrawal syndrome that develops after cessation of (or reduction in) prolonged, heavy consumption of opioids (e.g., morphine, heroin), included in
DSM-IV-TR,
DSM-5, and
DSM-5-TR. Features may include dysphoria or anxiety, nausea or vomiting, muscle aches, dilation of the pupils, piloerection (goose flesh) or sweating, diarrhea, fever, and insomnia. See also
substance withdrawal.