APA Dictionary of Psychology

n. any of a group of antipsychotic drugs, generally of intermediate potency, that resemble the phenothiazines in pharmacological activity and molecular structure. Like the phenothiazines, they are associated with cardiovascular and anticholinergic side effects, as well as extrapyramidal symptoms common to all dopamine-blocking agents. Their use has largely been supplanted by newer antipsychotics. Thioxanthenes include thiothixene (U.S. trade name: Navane), flupenthixol, and zuclopenthixol. Only thiothixene is currently available in the United States.