any of the hormones synthesized and released by the
thyroid gland. The primary thyroid hormone,
thyroxine (T
4), is metabolized to
triiodothyronine (T
3) within target tissues. Plasma levels of T
4 are much higher than those of T
3, but T
3 has the more potent physiological activity. Both hormones play a central role in regulating basic metabolic processes and the early development of the brain, and their excess secretion has major effects on functioning (see
congenital hypothyroidism;
myxedema;
thyrotoxicosis).
Calcitonin, a hormone released by parafollicular cells of the thyroid gland, plays a crucial role in calcium and phosphate metabolism.