a rare genetic metabolic disorder characterized by a deficiency of acid lipase, an enzyme needed to break down lipid molecules. The accumulation of lipids within cells can cause various symptoms, including enlarged and calcified adrenal glands, enlarged liver, enlarged spleen, malabsorption of nutrients, vomiting, diarrhea, and other signs of acute illness. Delayed psychomotor development may be present. Also called Wolman disease and primary familial xanthomatosis. [Moshe Wolman (1914–2009), Polish-born Israeli pathologist]