in
DSM–IV–TR, a pattern of repeated or compulsive use of opioids (e.g., morphine, heroin) despite significant opioid-related behavioral, physiological, and psychosocial problems and/or tolerance or characteristic withdrawal symptoms if use is suspended (see
opioid withdrawal). In
DSM–5 and
DSM-5-TR, opioid dependence and
opioid abuse have been subsumed into
opioid use disorder and are no longer considered distinct diagnoses. Also called
narcotic dependence. See also
substance dependence.